The 2022 U.S. Food and Drug Administration (FDA) Retail Food Protection Seminar, Safe Food Prep: It’s in Your Hands, was held virtually from September 19-22, 2022. Hosted by the National Association of County and City Health Officials, this annual seminar provided an opportunity for the FDA to discuss retail food issues of mutual concern with federal, state, local, tribal, and territorial (SLTT) partners. The 2022 seminar had a focus on norovirus, including assessing employee health, investigating norovirus related foodborne illnesses, and implementing successful employee health intervention strategies.